![]() Exclusion criteria were active uncontrolled infection or severe cardiac dysfunction, serious disabling conditions, symptomatic CNS metastases, radiotherapy within 2 weeks before enrolment, and concomitant use of any other drugs under investigation. We recruited patients aged older than 18 years with unresectable malignant mesothelioma with no evidence of disease progression after at least four cycles of first-line chemotherapy (with platinum and pemetrexed), who had a WHO performance status of 0-2, adequate organ function, and measurable or evaluable disease. We did a randomised, open-label, phase 2 trial in 18 hospitals in the Netherlands (NVALT19). We aimed to assess the efficacy and safety of switch-maintenance gemcitabine in patients with malignant mesothelioma without disease progression after first-line chemotherapy. Previous studies have investigated maintenance therapy, but none has shown a great effect. Electronic address: all patients with malignant mesothelioma eventually have disease progression after first-line therapy. 13 Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands.Electronic address: 1 Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands. 12 Department of Radiology, Netherlands Cancer Institute, Amsterdam, Netherlands.11 Department of Pulmonary Diseases, Zuyderland Medical Centre, Heerlen, Netherlands.10 Department of Pulmonary Diseases, Ziekenhuis groep Twente, Almelo, Netherlands.9 Department of Pulmonary Diseases, University of Groningen and University Medical Center Groningen, Groningen, Netherlands.8 Department of Lung Oncology, Maxima Medical Centre, Eindhoven, Netherlands.7 Department of Pulmonary Diseases, Deventer Hospital, Deventer, Netherlands.6 Department of Pulmonary Diseases, Amphia Hospital, Breda, Netherlands.5 Department of Pulmonary Diseases, Erasmus MC Cancer Institute, Rotterdam, Netherlands.4 Department of Pulmonary Diseases, Jeroen Bosch Hospital, Den Bosch, Netherlands. ![]() 3 Department of Pulmonary Diseases, Isala Hospital, Zwolle, Netherlands.2 Department of Biometrics, Netherlands Cancer Institute, Amsterdam, Netherlands.1 Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands.
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![]() In the play menu, add a break time where you enter a lodge with a warm fireplace and you can have hot chocolate, roast marshmallows and eat popcorn and maybe watch the outside, could be links to other ezone games you have installed that look like video game button link.Not surprising that ezone did this. Why not one easy mission level or watch ad to skip the level?So control another device with this, but any way to turn that feature off?Aside from that pretty smooth game play and nice graphics. Yep this just happened today, like bad luck day.And missions are all one level. You could go 'Snowblind' or turn into a total 'Powder Hound' just by looking at one of these funny snowboarding hats and crossing your eyes a little bit. The ones we've designed to go with our retro ski suits are a perfect example. The game seems to continue while the ad is playing so it does not give you that extra time to beat the level. Some of our funny snowboard hats are hysterical just because of the color choices. All in all this is a good game and, with some improvements, could become even better.ĭoes need some tweaks, but loving it.Only guy dudes for boarders? Really? A number one tweak needed here.Sometimes you just need to do one more task and opt to watch an ad, so you watch the whole ad, close the window and instead of getting more time for watching the ad, it just says failed so all that for nothing and so close. Finally, a way to tweak your tricks for more points would be good. Also, the addition of a cliff or an insanely large ramp or SOMETHING big to get some wicked air time would be good. ![]() Being able to move around a bit more is definitely something I would like to see. Another good update would be more free range in the levels. Crazy Snowboard has something for everyone: - In-air trick system: spin. A varied background would be a greatly appreciated addition and it would also fit into a tournament mode with races in different locations well. One of the most popular mobile snowboard games in the world with more than 15. And, although the background graphics are good, they get boring after the tenth mission. A tournament mode against other AI snowboard competitors and an online multiplayer mode would be great additions. First of all, there is a huge lack of competition in regards to playing against other snowboarders. However, it could still use a few tweaks to make this the must have game of the year. ![]() Its graphics are clean, the gameplay is good and varied, and it has a solid point reward system. These tricks can be learned on any snowboard but for riders who are serious about advancing in the park, we recommend a softer more forgiving park snowboard and medium flex snowboard bindings. In others you have to knock down snow men, or try to score a set number of points by. In some levels you have to collect letters that are scattered around the piste. The updated version of this game is incredibly fun and a great option for fans of the SSX Tricky snowboarding games. The game is a simple 3D snowboarding sim, that sees you sliding down a mountain with an expensive plank of wood strapped to your feet, performing a variety of different tasks. ![]() For my cart, it ended up having 24 wheels to account for all that. But if you’re making a track that goes up and down and left and right, it takes a lot more. If you made a track that just went left and right, without any hills, you’d need wheels that go left and right, like a car. Weirdly enough, it was the cart that gave him the most problems: “If you made just a straight track, with hills going up and down, you’d only need wheels that would articulate up and down. While the track took three months to plan, Sales says that it only took about two months to build, and consists of just PVC pipe and wood. He also started with the end of the track first, which he says was important because then he could make the hills larger as he went, as opposed to doing the bigger, more difficult hills first. Like, if you drop something 10 feet, you can calculate how far it will go, and there’s also g-force calculation for spinning things around in a curve, and since my coaster wasn’t a loop, you never put the end of the track any lower than the start because then you can’t fall off the end.” It was still largely trial-and-error, though, as Sales says that he’d build about 10 feet of track, see how it worked, then build another 10 feet, and so on. To build a roller coaster, Sales explains that it takes a knowledge of physics and algebra, but that, “the formulas are really easy. ![]() Years later, when he was the father of two young children, Sales poured his curiosity into a project to entertain them. He credits an influential high-school physics teacher with his career path as an engineer and says that whenever he’d visit an amusement park, he’d wonder how something worked, and from there, wondered if he himself could build something like it. Sales tells me that “curiosity, physics and problem-solving” was his motivation for his backyard project. Bruce Sales, California - The Speed Weasel And now that we’re all facing a summer in lockdown, these seemingly kooky hobbyists are looking like prescient geniuses who are better prepared to cope with a summer at home than just about anyone else. ![]() No, they decided to bring the experience home by building their own backyard roller coaster or, in some cases, an entire backyard amusement park. And we would have wrapped up the day with the huge Neighborhood Parade.īut even my love of theme parks pales in comparison to these guys, who weren’t content to visit a park only once in a while. My wife, daughter and I are season-pass holders at Sesame Place, and by this point in the year, we likely would have already been there two or three times to ride Captain Cookie’s High C’s Adventure and Oscar’s Rotten Rusty Rockets. In 1915, for example, Coney Island’s Rough Riders roller coaster-so named for President Teddy Roosevelt’s calvary during the Spanish-American Civil War- killed three people when a car went off the track 30 feet in the air.As a guy who loves Disney World, Six Flags and just about any other kind of theme park, it looks like this summer is shaping up to be a bit lacking. and abroad: A roller coaster collision in Spain that injured 33, another gondola accident in which a teenager fell 25 feet at a Six Flags in New York state, and two water ride accidents-one in California and one in the U.K.-that injured a 10-year-old and killed an 11-year-old.Īmusement park rides debuted in the late 19th century, and accidents on them have been documented since at least the early 20th century. As Kevin Lui noted in Time, there have already been at least four serious amusement park accidents since May of 2017, both in the U.S. Ohio Governor John Kasich (R) described it as “the worst tragedy in the history of the fair,” and called for all of the rides to be shut down while authorities investigate them. But on July 26, 2017, a whole row of the gondola fell off and two seatbelts malfunctioned, sending people into a freefall, according to The Washington Post. The pendulum ride was supposed to give passengers a thrill by swinging them in a circle on a gondola on the Columbus fairgrounds. ![]() Most recently, an Ohio State Fair attraction known as the Fire Ball malfunctioned, killing one rider and injuring seven others. Yet for almost as long, these rides have led to accidents that are scarily dangerous. For over a century, roller coasters and other amusement park rides have provided thrills by walking the line between scary and fun. ![]() Storm then transported all of the Gene Nationals to a dying village in Africa where they would eke out a new life for themselves. Mikhail was forced to transport Storm and the Gene Nationals back to Earth, but he escaped once more (presumably back to the Hill) ranting about his benefactor being displeased with him. If someone could reach the summit of the hill they were considered "fit" and worthy of being part of Gene Nation. The philosophy of "survival of the fittest" was the only thing which governed the society. In a world where time moves faster than normal, Mikhail had established a citadel for himself on the top of a massive hill. Mikhail did, however, survive, along with Callisto the former leader of the band of outcasts and a group of Morlocks who later descended to form Gene Nation. This eventually led to Colossus having a fallout with Xavier. The result being that many, including the X-Men, believed for a significant time that they all drowned to death, including Mikhail, which would become yet another source of grief in addition to the rest of his family's death, for Colossus in the near future. However after a battle with the X-Men, he collapsed and flooded the Morlocks' home. He escaped the X-Mansion and fled into the near tunnels, where he met and set himself up as leader of the Morlocks, the tunnel-dwelling mutants beneath New York City. Once back, however, Mikhail found it hard to adjust, and eventually went crazy, hearing and seeing his dead companions and loved ones in his mind, torturing him. With the help of Sunfire, Iceman, and Jean Grey to control the energy backlash, Mikhail and the team were able to close the rift and return to Earth, without any loss of life. However, having had one failed attempt that killed many, Mikhail was apprehensive to try it again. Eventually the team and Mikhail connected, and told that he had to close the void before it destroyed both this world and their home. When a team of X-Men, with his brother Colossus, traveled through the re-opened rift to try and seal it, Mikhail had exiled himself into the desert. ![]() He did so, but the backlash killed hundreds of his people, including his wife. During the fighting, the rift was opened, and only Mikhail's powers could close it. He married Tra-Mai-A-Zath, daughter of the world's ruler, the Worldly Avatar, and soon became a messiah-like figure and found himself embroiled in a civil war. He found a world, although he was the only survivor of his crew. Mikhail was sent by his superiors into an inter-dimensional void, counting on his powers to keep him and his comrades safe, to see what was on the other side. However, it was later discovered that the explosion was set up by the government who learned of Mikhail's powers and wanted to exploit them without him being encumbered by ties to the past. ![]() The older brother of Colossus, Mikhail was a Soviet Cosmonaut and was believed dead after a faulty mission where his space shuttle exploded. He sometimes collaborates his efforts with other villains such as Callisto, Omega Red, Apocalypse, and Mister Sinister. He was the only surviving member of his crew and returned to Earth mentally unbalanced, harboring a dangerous messiah complex. He was a Cosmonaut and the Russian Federal Space Agency tried to test his powers by sending him on a suicide mission. Mikhail is a mutant with substance-altering and dimension-hopping abilities. He first appeared in The Uncanny X-Men #284 (Jan. The character is the older brother of Colossus of the X-Men and Magik of the New Mutants. Mikhail Nikolaievitch Rasputin is a fictional supervillain appearing in American comic books published by Marvel Comics. Matter manipulation on the sub-atomic level ![]() Mikhail Rasputin from The Uncanny X-Men #374. Xbox Series S runs Kerbal Space Program at 1080p and also boasts better framerate. Playing Kerbal Space Program Enhanced Edition on PlayStation 5 and Xbox Series X results in a technical boost, with the action running at Quad high definition 1440p and an improved framerate over previous console versions. " Kerbal Space Program Enhanced Edition benefits from the advancements of new hardware, and we are excited to bring players a refreshed and refined experience with this release." We are so thankful to our community as we celebrate this monumental milestone of the game turning ten years old," said Nestor Gomez, Head of Production at Squad. “It has been an amazing journey with Kerbal Space Program. Kerbal Space Program Enhanced Edition builds upon a strong foundation and incorporation of numerous content updates and improvements over the past decade with the franchise celebrating its 10 th anniversary of the original game launch this week. ![]() Grounded in realistic aerodynamic and orbital physics, the game presents multiple challenges both in the assembly of functional spacecraft and the flight of these vehicles. In Kerbal Space Program, players take control of the development of the Kerbals’ space exploration program. “ Kerbal Space Program Enhanced Edition on the latest generation of consoles marks yet another great milestone for the game, introducing new players to the franchise, as well as providing existing console players with an upgraded experience for free.” “Today marks the celebration of the 10 th anniversary of the original release of Kerbal Space Program, and over the last decade the team has continued to iterate and grow this incredible space sim into what it is today,” said Grant Gertz, Franchise Producer at Private Division. Kerbal Space Program Enhanced Edition will be available digitally for purchase for $39.99. Xbox One owners of Kerbal Space Program Enhanced Edition can upgrade to Xbox Series X|S version upon launch free of charge. In addition, existing owners of Kerbal Space Program Enhanced Edition on PlayStation 4 will receive a free upgrade to the PlayStation 5 version. Originally released for PlayStation ®4 and Xbox One in January 2018, Kerbal Space Program Enhanced Edition on the latest consoles will also provide full support for a mouse and keyboard. Kerbal Space Program Enhanced Edition on these consoles will benefit from multiple hardware advancements and developments which allow for an upgraded resolution, improved framerate, advanced shaders, better textures, and additional performance improvements. ![]() NEW YORK-( BUSINESS WIRE)- Private Division, Squad, and BlitWorks today announced that Kerbal Space Program Enhanced Edition is coming to PlayStation ®5 and Xbox Series X|S this fall. ![]() ^ "Transfer roundup: Bournemouth sign Huddersfield's Philip Billing for £15m".^ "Philip Billing: Huddersfield contact police after midfielder racially abused on social media".^ a b Flere priser til Philip Billing ved Huddersfields prisuddeling, tipsbladet.dk,, Danish.^ PL-interesse for formstærk Billing‚ bold.dk, 31 January 2017.^ Billing forlænger med Huddersfield‚ bold.dk, 31 March 2016.^ "Cardiff City 3-2 Huddersfield Town".^ "Nottingham Forest 0-2 Huddersfield Town".^ "Huddersfield Town 0-2 Leicester City"."Prof-kontrakt til dansk Huddersfield-talent". ^ "Updated squads for 2017/18 Premier League confirmed".Career statistics Club As of match played 30 April 2023 Appearances and goals by club, season and competition He debuted in a 4–0 friendly win over the Faroe Islands on 7 October 2020. In March 2019, he received his first call-up to the Danish senior national team. In November 2018, Billing turned down an approach to switch his international allegiance to Nigeria. He played another qualifying match a week later, a 6–0 win against Lithuania. He earned his first cap for the Danish U21 team in a qualifying match for the 2019 European Championship against the Faroe Islands on 31 August 2017. On 9 March 2017, he was called up to the Denmark under-20 team to face the Czech Republic and Romania. He made his single appearance for the Danish U19s on 4 September 2014 as a substitute in their 2–1 win over Norway in Lyngdal. ![]() Billing is a Danish youth international, having represented the U19 and U21 teams. International career īilling was born in Denmark to a Danish mother and Igbo Nigerian father. Timed at just 9.11 seconds, his goal was the second fastest ever scored in the Premier League. On 4 March 2023, Billing scored the opening goal in a 3–2 away defeat to Arsenal. īilling scored eight goals in the Championship for the 2020–21 season, which was also his most prolific goalscoring season to date. This was one of two Bournemouth goals disallowed for handball in the match. īilling was involved in a controversial VAR decision in a 3–0 away loss to Burnley in the Premier League on 22 February, when his knock-down from a corner to Joshua King was judged to be a handball by the VAR officials. He then scored his first Premier League goal for the club, netting the opening goal against relegation rivals Aston Villa in a 2–1 win for the home side on 1 February. Billing scored his first goals for the club in the FA Cup Third Round fixture against Luton Town, as Bournemouth won the game 4–0. Billing made a strong start to his first season with Bournemouth, starting the first four Premier League games of the season and being nominated for the club's Player of the Month award for August. On 29 July 2019, Billing signed for Premier League AFC Bournemouth on a long-term contract for a £15 million fee. In March 2019, Billing suffered racial abuse on social media the matter was reported to police. After the season, Billing was named as the youth player of the season in Huddersfield and his goal against Cardiff City in November 2016 was voted goal of the season. He played 24 games and scored two goals in total in that season. "In-form" Billing was linked with a transfer to Premier League club Crystal Palace. He got his breakthrough in the 2016–17 season. After 10 good matches in the 2015–16 season, Billing signed a contract extension in March 2016. īilling got slowly more and more space in the squad. ![]() On 19 November 2016, he scored his second goal for the club with a volley from 32 yards out in a 3–2 loss against Cardiff City. His first goal for the club came from a 30-yard strike against Nottingham Forest at the City Ground in a 2–0 win for the Terriers on 13 February 2016. His first start for the Terriers came 18 months later in their 2–2 draw against Reading at the Madejski Stadium on 3 November 2015. After performing well for both the under-18s and under-21s, he made his first team debut for the club as a substitute in their 2–0 loss against Leicester City at the John Smith's Stadium on 26 April 2014. Billing signed a four-year professional contract in October 2013. After signing for Esbjerg in his native Denmark, he joined Huddersfield Town in 2013 on a youth contract. Philip Anyanwu Billing (born 11 June 1996) is a Danish professional footballer who plays as a midfielder for Premier League club AFC Bournemouth and the Denmark national team.Ĭlub career Huddersfield Town īilling was born in Copenhagen. ![]() ‡ National team caps and goals, correct as of 26 March 2023 *Club domestic league appearances and goals, correct as of 23:13, (UTC) Here is a screen-shot of the processing window, which you see is just like Topaz Adjust. The sheer volume of installed presets gave me a good hour of fun on the very first image that I opened in the software. This is partly due to the novelty of it, and partly because it truly is amazing photography software. It’s also my absolute favorite at the moment. Topaz B&W Effects is the newest plug-in from Topaz Labs. Using only the presets found on the left of the window, as well as the “I Feel Lucky” button, here is a sampling of results: Adjust Screenshot Topaz Adjust Color Blast Topaz Adjust Crisp Topaz Adjust Dark Ghostly Topaz Adjust I Feel Lucky Topaz Adjust Mild Color Pop 3 Topaz Adjust Mild Color Pop 4 Topaz Adjust Mild Color Pop Topaz Adjust Painting Venice 2 Topaz Adjust Portrait Smooth Topaz Adjust Simplify 2 Topaz Adjust Simplify 3 Topaz Adjust Simplify Topaz-Adjust-Sketch-Dark-Charcoal Topaz B&W Effects Adjust can bring out incredible detail in a photo as well as soften or “simplify” the image. It does such a great job of tone mapping a single JPEG or TIFF, which isn’t a strong point for most HDR software in my experience. Some are straight from the camera and a few are obvious photo-manipulations processed in Photoshop:Īdjust is the first plug-in I downloaded and tried from Topaz Labs and I fell in love with it instantly. Here are the original images used to evaluate the plug-ins. Yes, the sheer number of images in this review might be a bit much! Topaz Labs Bundle Review Also, I will include a screen-shot of the processing window, and will include any random thoughts I may have. I have processed quite a few photos in each of the Topaz Labs plug-ins which will be included in this review. This can potentially save a lot of time as you don’t have to open your images in Photoshop first. Also included in the bundle is Fusion Express, which allows you to use the plug-ins within Aperture, Lightroom and iPhoto. There are now a total of eight Topaz Labs Photoshop plug-ins, which are all included in the software bundle. ![]() The trial versions are fully functional and they do allow you to save your images without watermarks. You can download the bundle of Topaz Labs plug-ins and use them free for a full thirty days. While it makes huge economic sense to purchase the entire bundle of plug-ins, you can purchase each plug-in separately if you don’t need all of them. ![]() I’ve written a few short reviews on a handful of Topaz plug-ins, but this is my first comprehensive review of the entire bundle. The Topaz Labs bundle of photography software is my absolute favorite image processing tool. ![]() Category: Featured, Photography Software Reviews Tags: coupon, featured, topaz Leave a Comment These descriptions refer to the Evil Chicken eating some of them. ![]() OSRS POSTIE PETE UPDATEīefore its update to include a locked gate, the keys originally disabled three magical barriers which blocked the exit, which did not have a door at all.If a player talks to Prison Pete after he escorts someone else back to RuneScape, he will say, "Don't mind me, I was just leaving.".Alas, poor Yojllik, I knew him backwards! (Yojllik is Killjoy backwards) This is a reference to a line in Shakespeare's Hamlet, which the title character says when looking at a skull: "Alas, poor Yorick, I knew him!".This is odd, as according to Evil Bob, there is no Evil chicken in ScapeRune, but rather the Cheery old chicken. It's rare, but possible for a balloon animal to teleport into Prison Pete's cell and attempt to teleport him away.Pirate Pete is a pirate from Mos Le'Harmless currently in the service of Captain Braindeath. Before the events of Rum Deal, Braindeath sent Pete to find help in fighting the invasion of Captain Donnie. Players must talk to him to start the quest, and he is located on a dock near the Ectofuntus. He also offers the player transport to Braindeath Island after the quest. He is the only person who knows how to reach Braindeath Island, and will distract and knock out anyone wishing to go there to ensure the island's location remains secret. When travelling back and forth, players are knocked unconscious every time, which does not deal any damage. Players will then wake up on the island, which does not appear on the RuneScape map. ![]() Second, when enough consumers are sophisticated and the naive have a relatively low willingness to pay for their preferred contract, exploitative contracts decline in frequency and may actually vanish. First, when consumers shop, neither contract type is priced monopolistically, and competitive pricing sometimes obtains. Firms offer an exploitative contract or a naive contract to a consumer population partitioned in two ways: some consumers are sophisticated while others are naive, and some consumers search for preferred contracts while others visit one firm. Competition among firms is analyzed with a search equilibrium model. Consumers differ cognitively, some being more prone to err (the “naive”) than others (the “sophisticated”). read more read lessĪbstract: This article asks whether competition can ameliorate the consequences of cognitive error. ![]() Abstract: Purpose – Credit card bankruptcies in Malaysia trebled from 2006 to 2007 and study loan defaults increased by 103 percent in the same period In response to this, the paper aims to investigate the level of general financial and product awareness among young adults The two research questions addressed are: how do demographic factors (age, gender and education level) influence the general financial awareness, and whether undertaking a business degree promotes greater financial and product awareness amongst youth todayDesign/methodology/approach – A survey method was employed using a sample of 280 students at a private higher education institution in Subang Jaya, Malaysia The study also develops valid and reliable scales for general financial awareness and financial product awareness Hypothesis testing was conducted using multivariate analysis of covarianceFindings – The findings of the study revealed that the level of education and majors influence general and financial product awareness among youths. Krisp for Individuals can work great for all of the remote workers, extreme vagabonds & digital nomads, location independent pals and freelancers out there. Stay tuned until the end though, we have a generous friend referral program you definitely wanna check out! Krisp for Individuals We want to make sure everyone benefits from Krisp, and we tailored free and paid plans separately both for individuals and teams. Now that we got this covered, let’s see what other exciting new features we have come up with thanks to you! Krisp for Individuals & Teams We want to make sure your calling experience is fully enhanced, pleasurable and productive and we can’t wait for you to give Krisp for Windows a try! Any microphone & speaker, both wired and wireless.Any headset or headphones of your choice.Any communications app that allows you to change the audio settings. ![]() The coolest part is that Krisp for Mac & Windows works with: You can speak and listen without noise while in a call with your friends, business partners or digital nomad buddies at anytime from anywhere! Of course, the app’s noise cancellation is bi-directional, which means that it removes both incoming and outgoing noise on both ends of the call. It works the same way as Krisp for Mac, which means you get to remove background noise during your calls without any effort. We are officially launching our Krisp app for Windows. Loving it? Let’s check out the most important news of the day: Krisp for Windows is Now Available! By the way, we have a cool new interface for Krisp for Mac! And that’s not the only thing – we have more surprises packed and ready for you to open it. Krisp for Windows is featured on Product Hunt! Come show us some love □Īfter a lot of sleepless nights our ultimate noise cancelling app is now available for both Mac and Windows. Thanks to your endless love and support, we finally made sure you get the most out of Krisp! ![]() ![]() Through all this time we have learned a lot from your feedback about Krisp, and we thought of more ways to make the app more enjoyable and useful for you. |
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